CEBPA/SPI1 multiomic analysis

Sequence context and partner availability specify divergent cell fates from a single transcription factor

Shiny app for CITE-seq and scATAC analysis of CEBPA, SPI1 and CEBPA+SPI1 reprogramming of mouse embryonic fibroblasts.

Hammad Farooq^#, Kenneth Joves^#, Aydolun Petenkaya^#, Itay Solomon^#, Eva H.W. Leung, Sen Zhang, Mary Menhart, Ali Farhat, Lin Du, Nissim Hay, Sandra Pinho^*, and Constantinos Chronis^*

^# These authors contributed equally. ^* Correspondence

Additional atlas view

RNA gene

CellBender RNA.

ADT feature

CellBender CLR ADT with matched RNA.

ChromHMM model - Fig. 8b

ChromHMM state - Fig. 8c / Fig. S8b

Per-cell log2(1 + RPKM).

scATAC accessibility tracks - Fig. 8f / Fig. 8g

Gene or mm10 locus

Cluster tracks

RPKM BigWigs; selected tracks share the same y-axis scale. Track order follows the selection order.